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Molecule glue drugs shake up cancer care

One of the biggest advances in pancreatic cancer in decades came out of a crazy idea born in a Harvard University lab.Chemical biologist Gregory Verdine believed you could fight disease-causing proteins hidden inside cells by chemically gluing them to something else in the body and smothering them."Everybody told us this is crazy, that it would never work," he recalls.Revolution Medicines, which bought one of Verdine's companies in 2018, recently announced that one of its drugs doubled the typical survival time for patients with aggressive forms of the disease, from 6.7 months to 13.2 months. The full results from the company's final-stage trial are expected to be the star of the show at the annual confab of cancer doctors in Chicago this weekend.Spurred by the success of RevMed, numerous companies are now racing to develop similar drugs, dubbed "molecular glues", which can be used to treat a variety of ailments. And investors and pharmaceutical companies wi...

Delhi HC upholds TRAI’s 12-minute ad cap

The Delhi High Court on Friday dismissed a batch of petitions filed by television broadcasters in 2013 challenging the Telecom Regulatory Authority of India’s (TRAI) 12-minute-per-clock-hour cap on television advertisements, bringing closure to a legal battle that had remained pending for nearly 13 years.The ruling is expected to impact television broadcasters, particularly free-to-air channels that rely heavily on advertising revenue to sustain operations, as the dismissal of petitions clears the way for enforcement of advertising limits that had remained effectively stayed for years.A division bench of Justice Anil Kshetarpal and Justice Amit Mahajan held that TRAI acted within its statutory authority in prescribing limits on television advertisements to protect consumer interests and improve the quality of viewing experience.Also read | Ad slowdown dulls impact of HC relief on TV landing page revenuesThe petitions, filed by a broad set of broadcasters including general entertainment...

India, China step up border dialogue

New Delhi: Senior officials of India and China discussed delimitation, border management, mechanism building and cross-border cooperation at a meeting on Wednesday in Beijing. Both sides also decided to prepare for National Security Advisor Ajit Doval's upcoming visit to China.During the 35th meeting of the working mechanism for consultation and coordination on India-China border affairs, the Indian side stressed on an early meeting of the next expert level mechanism on trans-border rivers.The two sides also agreed to work together to make "substantive preparation" for the next meeting of special representatives (SRs) which would not only focus on border issues but also other geopolitical matters including regional issues. The meeting-if held prior to Chinese President Xi Jinping's India trip for the September 12-13 Brics Summit- will help to prepare for a possible meeting between Prime Minister Narendra Modi and Xi on the sidelines of the summit.Also read | Billionai...

Cabinet nod: Sarthak PDS gets Rs 25,530 cr

New Delhi: The Union Cabinet on Wednesday approved an outlay of Rs 25,530 crore for Sarthak Public Distribution System (PDS) scheme to modernise it and ensure food security for nearly 80 crore beneficiaries. The outlay is for the next five years.Apart from modernising the distribution and logistics network, the scheme seeks to strengthen fair price shops (FPS) and to assist state agencies for intra-state movement of food grains.The government has also decided to revise the norms of Central assistance to meet the expenditure incurred by states and UTs on intra-state movement and handling of foodgrains and FPS dealers' margin and continuation of the existing funding pattern of central assistance. It will provide a unified, citizen-centric, intelligent and interoperable PDS architecture that ensures last-mile service delivery, minimizes leakages and strengthens the nation's commitment to food security under NFSA, with the merged scheme to operate up to March 2031, the government s...

Pak urges India to respect Indus Water Treaty

from Economic Times https://ift.tt/R5mQAIZ

Govt assures 78 days of oil amid MPs' concerns

New Delhi: Concerns over fuel availability, shipping disruptions and fertilizer supplies dominated a Parliamentary panel meeting on Monday, with MPs questioning officials over reports of long queues and rationing at petrol pumps. Officials maintained that India has adequate reserves, with crude stocks sufficient for 78 days.Officials informed the Parliamentary Standing Committee on Transport, Tourism and Culture that 37 Indian ships remain stranded in West Asia due to the closure of the Strait of Hormuz.Also Read: Petrol, Diesel price hike: Fuel rates increased for fourth time in less than two weeks Only around five vessels have secured cover under the Bharat Maritime Insurance Pool.According to sources, while the government reiterated there was no shortage petrol, diesel and LPG, opposition MPs described the responses as unsatisfactory, citing the absence of granular data.On shortage of bitumen, MPs said officials failed to provide clear answers. Officials linked the supply stress to ...